Functional Lab Testing

Functional health is dynamic and ever-changing, shaped by hormonal shifts, environmental factors, genetics, nutrition, and lifestyle. Addressing that complexity requires a holistic, personalized approach, and functional lab testing is a cornerstone of that process. By using comprehensive hormone, thyroid, microbiome, genetic, and other specialized tests, we can uncover the underlying causes of symptoms rather than simply managing them.
Identifying imbalances, deficiencies, and dysfunction early makes it possible to take a proactive approach to care, better manage chronic conditions, and build personalized strategies that optimize health over time. It’s an invaluable tool for anyone seeking to understand their body more deeply and achieve lasting wellness.

These are the key functional lab tests that can transform the way we approach health, ranging from hormones to gut health to micronutrient deficiencies.

Functional Lab Quiz – Click here to discover which advanced laboratory test(s) may help uncover the root cause of your symptoms.

HPA Profile by NeuroScience

The HPA Profile by NeuroScience is built on a foundation of neurotransmitter testing. At its core, this profile measures the key neurotransmitters that regulate nervous system function—including dopamine, serotonin, GABA, glutamate, and the catecholamines (epinephrine and norepinephrine). Neurotransmitter imbalances are frequently at the root of poor sleep, anxiousness, fatigue, mood changes, and difficulty managing stress.

From this neurotransmitter baseline, the profile can be expanded to assess the body’s stress-response system (the Hypothalamic-Pituitary-Adrenal axis) by adding salivary adrenal hormones such as cortisol and DHEA. This layered approach helps identify whether nervous system imbalance, adrenal dysfunction, or both are contributing to a patient’s symptoms—allowing for targeted interventions like stress-management techniques, lifestyle modifications, and supplementation.

This testing is appropriate for both men and women, with panel options tailored to age and hormone-related needs (including men transitioning to andropause and individuals over 40 approaching menopause or andropause).

Sample Report

See pricing within the various tests below.

HP (urine test only)

The HP Profile evaluates seven neurotransmitters to assess nervous system function. This profile is ideal for individuals of any age reporting quality-of-life complaints such as poor sleep, anxiousness, fatigue, mood issues, and more.

Neurotransmitters (urinary): Dopamine, Epinephrine, GABA, Glutamate, Norepinephrine, Phenylethylamine, Serotonin

HP (urine test only) = $355

HPA (urine and saliva)

The HPA Profile evaluates hormones and neurotransmitters to assess adrenal gland and nervous system function. This profile is ideal for individuals reporting quality-of-life complaints related to stress such as poor sleep, anxiousness, fatigue, mood issues, and more.

Neurotransmitters (urinary): Dopamine, Epinephrine, GABA, Glutamate, Norepinephrine, Phenylethylamine, Serotonin

Adrenal Hormones (salivary): Cortisol (4pts: morning, noon, evening, night), DHEA-S (2pt)

HPA (urine and saliva) = $410

HPA-G Basic (urine and saliva)

The HPA-G Basic Profile evaluates hormones and neurotransmitters to assess nervous and endocrine system function. This profile is ideal for men suffering from hormone-related complaints. It is especially useful for men transitioning to andropause.

Neurotransmitters (urinary): Dopamine, Epinephrine, GABA, Glutamate, Norepinephrine, Phenylethylamine, Serotonin

Hormones (salivary): Cortisol (4pts: morning, noon, evening, night), DHEA-S (2pt), estradiol (E2), progesterone, testosterone

HPA-G Basic (urine and saliva) = $485

HPA-G Complete (urine and saliva)

The HPA-G Complete Profile evaluates hormones and neurotransmitters to assess nervous and endocrine system function. This profile is ideal for individuals suffering from complaints typically related to hormones and is especially useful for all individuals over the age of 40 as transitions to menopause and andropause begin.

Neurotransmitters (urinary): Dopamine, Epinephrine, GABA, Glutamate, Norepinephrine, Phenylethylamine, Serotonin

Hormones (salivary): Cortisol (4pts: morning, noon, evening, night), DHEA-S (2pt), estrone (E1), estradiol (E2), estriol (E3), progesterone, testosterone

HPA-G Complete (urine and saliva) = $515

Comprehensive Thyroid Panel

Thyroid health plays a crucial role in regulating metabolism, energy levels, mood, and overall well-being. Thyroid imbalances are often behind unexplained weight changes, fatigue, hair loss, or mood swings, and are relevant to both men and women across all life stages.

Blood Spot Thyroid Panel (recommended — no phlebotomy required). Our recommended option is a comprehensive at-home blood spot panel that goes well beyond TSH alone, with no blood draw or phlebotomist visit needed. It includes:

TSH (thyroid stimulating hormone)
Free T3 (fT3)
Free T4 (fT4)
T4
Tg (thyroglobulin)
Anti-TPO / TPOab (thyroid peroxidase antibody)

This thorough approach helps detect hypothyroidism, hyperthyroidism, and autoimmune thyroid disease such as Hashimoto’s thyroiditis. The sample report below reflects this blood spot panel.

Blood draw option (includes Reverse T3). For patients who want Reverse T3 assessed, a blood draw panel is available. Please note this option is more expensive and requires a visit to a phlebotomist, which incurs an additional fee.

Sample Report

DUTCH and Comprehensive Hormone Testing

DUTCH Complete is one of the most advanced hormone testing tools available—a non-invasive, at-home dried urine test that measures key hormones and their metabolites, including estrogen, progesterone, testosterone, cortisol, and melatonin. It goes beyond basic blood testing to reveal hidden imbalances tied to fatigue, mood changes, hot flashes, acne, weight changes, and irregular cycles, and is especially valuable in perimenopause, menopause, and conditions such as PCOS.

DUTCH Complete = $550

DUTCH Plus builds on the Complete panel by adding saliva samples that assess the Cortisol Awakening Response (CAR) and include an overnight (insomnia) cortisol sample—providing a deeper look at stress physiology and sleep-related cortisol patterns.

DUTCH Plus = $660

Pricing includes lab work and review consultation.

DUTCH Sample Report

DUTCH Plus Sample Report

DUTCH Cycle Mapping

DUTCH Cycle Mapping offers detailed insight into a woman’s hormonal fluctuations across her menstrual cycle. Rather than a single snapshot, samples are collected at points spread across the full menstrual cycle, with the exact timing tailored to each individual’s situation (this is not a daily, month-long collection). This provides a precise understanding of the hormonal changes occurring at different phases of the cycle and is particularly useful for women with irregular cycles or those navigating fertility challenges.
Cycle mapping can detect issues like luteal phase defects, estrogen dominance, or inadequate progesterone production—common contributors to menstrual irregularities, infertility, or hormonal symptoms. This test allows your practitioner to tailor treatment based on your unique hormonal patterns.

Cycle Mapping is offered paired with a full hormone panel as Cycle Map Complete or Cycle Map PLUS (the standalone Cycle Map is not ordered on its own).

DUTCH Cycle Map Complete = $730
DUTCH Cycle Map PLUS = $825

Pricing includes lab work and review consultation.

Sample Report

GI-MAP Testing

The GI-MAP is a comprehensive stool test that utilizes qPCR technology to detect parasites, bacteria, fungi, and more, allowing practitioners to create personalized treatment protocols to address gut dysfunction. This test also includes an add-on for the leaky gut marker zonulin.

GI-MAP (including review and consultation) = $575

Sample Report

BiomeFx

BiomeFx is a comprehensive, at-home stool test that uses whole genome shotgun metagenomic sequencing for a complete microbiome analysis. Shotgun sequencing provides the most granular view of the microbiome—all genes are sequenced, enabling both taxonomical and functional profiling. The test analyzes metabolite production, pathway-specific insights, dysbiosis ratios, keystone species, pathogen balance, and microbial interactions.

BiomeFx is also partnered with secure Jona AI analysis, advancing beyond microbial composition to reveal the microbiome’s theater of activity, how microbes interact, produce metabolites, and respond to their environment to influence health. Jona AI evaluates microbiome findings against more than 220,000 studies (with real-time updates) to identify personalized microbiome patterns aligned with your areas of health interest.

BiomeFx Cost (includes results review and consultation) = $595

Sample Report

Organic Acids Testing (OAT)

Organic Acids Testing (OAT) offers a powerful window into your body’s internal biochemistry, often uncovering hidden imbalances long before they appear on standard labs. This at-home urine assay quantifies 76 key metabolites reflecting pathways like mitochondrial energy production, detoxification, gut microbial activity, neurotransmitter metabolism, oxalate handling, and nutrient cofactor status. Because these organic acids are downstream products of cellular processes, they can reveal subtle dysfunctions—whether from gut dysbiosis, toxin exposure, or metabolic stress—giving you a far more complete picture than isolated markers alone.

At Longevity Health Center, we pair your OAT results with one-on-one coaching and clinical guidance so you can turn data into action. With clear insight into where your system is under strain, we help craft interventions tailored to your needs—whether that’s mitochondrial support, microbial balancing, detox pathways, or targeted nutrition. The OAT is also repeatable (every 3–6 months) so you can track progress over time and refine your strategy for long-term vitality.

At home urine sample.

OAT Cost (including review and consultation) = $485

Sample Report

MycoTox

The MycoTOX Profile is a comprehensive mycotoxin test. It uses advanced mass spectrometry to screen for eleven different mycotoxins, from 40 species of mold, in one urine sample. At home urine sample.

MycoTox Cost (including review and consultation) = $455

Sample Report

Myco-Metabolic Panel (OAT+MycoTox)

The Myco-Metabolic Panel integrates the MycoTOX Profile with the Organic Acids Test (OAT). Assessing organic acids along with mycotoxins provides more insight into possible mold and mycotoxin exposure along with their potential effects on mitochondrial function, detoxification capacity, and nutrient status.

At home urine sample.

Myco-Metabolic Panel Cost (including review and consultation) = $715

($225 savings)

OAT Sample Report

MycoTox Sample Report

Hair-Tissue Mineral Analysis (HTMA)

HTMA is a comprehensive nutritional test that analyses a small hair sample to reveal your body’s mineral status over the preceding months. Unlike blood tests, which reflect only a snapshot in time, HTMA provides a long-term picture of how well your body is absorbing and utilizing essential minerals such as calcium, magnesium, sodium, potassium, zinc, copper, and selenium. It also screens for the presence of toxic heavy metals like lead, mercury, arsenic, and cadmium. HTMA also includes an expanded panel of additional trace elements and key mineral ratios that can offer valuable insight into thyroid and adrenal function, energy production, immune health, and detoxification capacity.

HTMA Cost = $195 (includes results review and consultation)

Sample Report

DNA Methylation Pathway Profile

The DNA Methylation Pathway Profile screens for a variety of genetic changes (single nucleotide polymorphisms) that may impact the function of important biochemical processes such as methionine metabolism, detoxification, hormone balance, and Vitamin D function.

DNA Methylation Pathway Profile (including review and consultation) = $695

Sample Report